as noted above, FWC or closed cooling has the engine full of antifreeze and the manifolds too if a full system (half does only block)...so your main job there is to get the water out of the raw water side (heat exchanger and impeller housing/lines).
With a raw water cooled engine, if you want to fill with AF after draining, its not necessary to remove the thermostat. Disconnect the big hose that connects the thermo housing and circulating pump, at the top connection (thermo housing neck), leave the bottom one to the pump on. Then just pour in AF the hose till it comes out the neck of the thermo housing. Then the engine's filled, re-connect the hose at the thermo housing and you're done filling the block...