This was a hotly debated topic when Ethenol first started making an appearance. Now it seems most folks have settled on how they like to handle it. I have always left my tanks under 1/4 full and used lots of marine fuel stabilizer. I have never had a problem. Ethanol binds with water vapor. The more gas you have in the tank, the more ethenol and the more chance for contamination. Leaving the tank full does not make you immune to this as all tanks are vented to the outside. Also, the less gas in your tank at the end of the season, the less that will be subject to phase separation over the winter. When you add fuel in the spring, it's fresh, not six months old. And finally, if you do have a problem with the fuel in your tank over the winter, in my case getting rid of 20-30 gallons is a lot easier than trying to get rid of 140 gallons.
Having said all of this there are plenty of people on this board that leave their tanks full or partially full and have never had a problem, so you just never know.